Indication
• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes. • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase producing strains), Moraxella Catarrhalis (including beta-lactamase producing strains) or Streptococcus pyogenes. • Acute Bacterial Maxillary Sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non beta-lactamase producing strains only). • Lower Respiratory Tract Infections including pneumoniae, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase and non penicillinase producing strains), Streptococcus pyogenes, Escherichia coli. • Acute Bacterial Exacerbations of Chronic Bronchitis and Secondary Bacterial Infections of Acute Bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains) or Haemophilus parainfluenzae (beta-lactamase negative strains). • Skin and Skin-Structure Infections caused by Staphylococcus aureus (penicillinase and non-penicillinase producing strains), Streptococcus pyogenes, Escherichia coli, Klebsiella spp. and Enterobacter spp. • Urinary Tract Infections caused by Escherichia coli or Klebsiella pneumoniae. • Bone and Joint Infections caused by Staphylococcus aureus (penicillinase and non-penicillinase producing strains). • Uncomplicated and Disseminated Gonococcal Infections due to Neisseria gonorrhoeae (penicillinase and non-penicillinase producing strains) in both males and females. • Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi. • Septicemia caused by Staphylococcus aureus (penicillinase and non-penicillinase producing strains), Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae (including ampicillin-resistant strains) and Klebsiella spp. • Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin resistant strains) Neisseria meningitis and Staphylococcus aureus (penicillinase and non-penicillinase producing strains). • Switch Therapy (injectable to oral) after surgery when patient’s condition is improved.
Dosage And Administration
Side Effects
Generally Cefuroxime and Clavulanic Acid are well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic Acid combination may result in overgrowth of nonsusceptible microorganisms.
Contraindications
Cefuroxime & Clavulanic Acid should be given with care to patients receiving concurrent treatment with potent diuretics & who have history of colitis. Patients with known allergy to cephalosporins & pseudomembranous colitis are contraindicated.
Drug Interactions
Concomitant administration of probenecid with Cefuroxime & Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.
Precautions
Use in Pregnancy & LactationDuring pregnancy: While all antibiotics should be avoided in the first trimester if possible. However, Cefuroxime & Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. During lactation: Cefuroxime & Clavulanic Acid is excreted into the breast milk in small quantities. However, the possibility of sensitizing the infant should be kept in mind.
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