Indications
Description
This contains all 18 essential and non-essential amino acid needed for protein synthesis. The amino acid composition is such that positive nitrogen balance can be achieved in the postoperative period and during extended periods of intravenous nutrition.
This is a sterile aqueous solution of crystalline Amino Acids and D-Sorbitol with electrolytes, which are necessary as the nitrogen, sources for parenteral nutrition. Nitrogen is provided in the form of essential and non-essential amino acids. The solution is clear, colorless, having a pH lying in the range of 6.0 to 7.0.
Pharmacology
Amino acids is a sterile aqueous solution of Amino Acids IV Infusion and 10% Glucose with electrolytes, which are necessary as the nitrogen sources for parenteral nutrition. Nitrogen is provided in the form of essential and non-essential amino acids.
Pharmacodynamics: Amino Acid IV Infusion with 10% Glucose and Electrolytes contains amino acids and electrolytes, which are all present in ordinary food. Apart from the nutritive properties Amino Acid IV Infusion with 10% Glucose and Electrolytes should have no specific pharmacodynamic effects. To optimize the utilization of supplied amino acids, adequate energy should be supplied in the form of carbohydrates (preferably glucose) and fat.
Pharmacokinetics: The principle pharmacokinetic properties for Amino Acid IV Infusion with 10% Glucose and Electrolytes are essentially the same as for amino acids supplied by ordinary food. However, the amino acids of dietary protein first enter the portal vein and then the systemic circulation, while intravenously infused amino acids reach the systemic circulation directly.
Preclinical safety studies with Amino Acid IV Infusion with 10% Glucose and Electrolytes demonstrated good tolerance.
Dosage & Administration
The nitrogen requirement for maintenance of body protein mass depends on the patient’s condition (nutritional state and degree of metabolic stress).
- No or minor metabolic stress and normal nutritional state: 0.10-0.15 g nitrogen/kg/day,
- Moderate metabolic stress with or without malnutrition: 0.15-0.20 g nitrogen/kg/day,
- Severe catabolism as in burns, sepsis and trauma: up to 0.20-0.25 g nitrogen/kg/day.
The dosage range 0.10-0.25 g nitrogen/kg/day corresponds to 15-35 ml Amino acids IV/kg/day.
In obese patients, the dose should be based on the estimated ideal weight. Depending upon patients requirements, 1000-2000 ml Amino acids IV may be infused intravenously per 24 hours. Amino acids IV should be infused slowly, at rates 1.4-2.8 ml (30-60 drops) per minute.
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