Only for the use of Medical Professionals
Clonium®
Description
Clonium® is a preparation of Clonazepam which exerts its antiseizure and antipanic effects by
enhancing activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter
in the central nervous system.
Indication
1. All clinical forms of epileptic disease and seizures in infants, children and adults
including-
Atypical absence (Petit mal)
Primary or secondary generalized tonic-clonic (grand mal)
Tonic or clonic seizures
Partial (focal) seizure
Myoclonic seizures
Myoclonous
2. Panic attack
3. Bipolar affective disorder
4. Drug-induced dyskinesia
5. Choreiform movement
6. Fulgurant pain
7. Tourette’s syndrome
8. Resistant depression
9. Nocturnal myoclonus
10. Trigeminal neuralgia
Dose
Adult and elderly
Initial dose: 1 mg/day in divided dose (Elderly 0.5 mg) at night for 4 nights
Maintenance dose: According to response the usual maintenance dose of 4-8 mg daily in 3-4
divided doses over 2-4 weeks.
Infants & children
Up to 1 year: 0.25 mg/day in divided dose increases up to 0.5-1 mg
Up to 5 year: 0.25 mg/day in divided dose increases up to 1-3 mg
Up to 5-12 year: 0.5 mg/day in divided dose increases up to 3-6 mg
Use in pregnancy and lactation
Use of Clonazepam during pregnancy and lactation should be avoided. Clonazepam is excreted
into breast milk. Mothers receiving clonazepam should not breast-feed their infants.
Side effects
The common side effects of Clonazepam are fatigue, muscle weakness, dizziness, light
headedness, somnolence, hypersalivation in infants, occasional hypotonia and co-ordination
disturbances.
Clonazepam
Contraindications
Patients with known hypersensitivity to benzodiazepines or any other drug excipients; acute
pulmonary insufficiency; severe respiratory insufficiency, sleep apnoea syndrome , myasthenia
gravis and severe hepatic insufficiency.
Precautions
When used in patients in whom several different types of seizure disorders coexist,
clonazepam may increase the incidence or precipitate the onset of generalized tonic-clonic
seizures. The abrupt withdrawal of clonazepam, particularly in those patients on long-term,
high-dose therapy, may precipitate status epilepticus. Caution should be exercised in the
administration of the drug to patients with impaired renal function. Clonazepam may produce
an increase in salivation. Clonazepam should be used with caution in patients with chronic
respiratory diseases.
Drug interaction
The CNS-depressant action of benzodiazepines class of drugs may be potentiated by alcohol,
narcotics, barbiturates hypnotics, antianxiety agents, the phenothiazines, thioxanthenes and
butrophenone classes of antipsychotic agents, mono-amino oxidaes inhibitors and the tricyclic
antidepressants and other anticonvulsants.
Overdose
Symptoms of clonazepam overdosage include somnolence, confusion, coma, and diminished
reflexes. Management treatment includes monitoring of respiration, pulse and blood pressure,
general supportive measures and immediate gastric lavage. Intravenous fluids should be
administered and an adequate airway maintained.
Pharmaceutical precautions
Store in a cool place. Protect from light.
Presentation
Clonium® 0.5 mg tablet: Beige colored, round tablet. Each tablet contains Clonazepam BP
0.5mg.
Clonium® 1 mg tablet: Light pink colored, round tablet. Each tablet contains Clonazepam BP
1mg.
Clonium® 2 mg tablet: Light orange tablet. Each tablet contains Clonazepam BP 2mg.
Clonium 2mg 1pcs
৳ 14
Description
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