Indications
• Epilepsy; specially myoclonic & absence seizures
• Panic Disorder
• Convulsion
• Anxiety Disorders
Dosage & Administration
Seizure Disorders
Adults
The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses.
Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately
controlled or until side effects preclude any further increase. Maintenance dosage must be
individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg.
Pediatric Patients
Clonazepam is administered orally. In order to minimize drowsiness, the initial dose for infants and
children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day
but not to exceed 0.05 mg/kg/day given in two or three divided doses.
Panic Disorder
The initial dose for adults with panic disorder is 0.25 mg bid. An increase to the target dose for most
patients of 1 mg/day may be made after 3 days. The recommended dose of 1 mg/day is based on the
results from a fixed dose study in which the optimal effect was seen at 1 mg/day.
Contraindications:
Clonazepam should not be used in patients with a history of sensitivity to benzodiazepines, nor in
patients with clinical or biochemical evidence of significant liver disease. It may be used in patients with
open angle glaucoma who are receiving appropriate therapy but is contraindicated in acute narrow
angle glaucoma.
Side Effects
The most frequently occurring side effects of Clonazepam are CNS depression. Experience in
treatment of seizures has shown that drowsiness has occurred in approximately 50% of patients and
ataxia in approximately 30%. In some cases, these may diminish with time; behavior problems have
been noted in approximately 25% of patients. Abnormal eye movements, aphonia, coma, tremor,
vertigo, Confusion, depression, amnesia, hallucinations, hysteria, increased libido, insomnia, psychosis
& palpitations may occur.
Use in Pregnancy and Lactation
Clonazepam should be used in pregnancy only if the potential benefits outweigh the potential risk to the
fetus and it is recommended that women receiving Clonazepam should not breast – feed.
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