INDICATIONS
Filmet is indicated in the prophylaxis and treatment of infections in which anaerobic
bacteria have been identified or are suspected to be the causes. It is particularly
suited for patients who can not retain oral medication and for patients in whom
desired serum concentration have to be attained rapidly and reliably.
Filmet is indicated :
I . In the prevention of post operative infections due to anaerobic bacteria.
2. In the treatment of
a. Intra abdominal infections – appendicitis, cholecystitis, peritonitis, liver abscess
and post operative wound infections;
b. Gynaecological and obstetrical infections – puerperal sepsis, pelvic cellulitis,
pelvic peritonitis;
c. Respiratory infections – necrotizing pneumonia, empyema, lung abscess;
d. Central Nervous System infections – meningitis, brain abscess;
e. Miscellaneous infections – septicaemia, bacteremia, osteomyelitis, gas gangrene.
DOSAGE AND ADMINISTRATION
Filmet may be diluted with appropriate volumes of normal saline, dextrose-saline, dextrose 5% w/v or potassium chloride (20 and 40 mmol) infusions.
For prophylaxis and Adults Children treatment of anaerobic infections
Dose 100 ml (500 mg) 1.5 ml (7.5 mg) per kg body immediately before, weight every 8 hours
during or after operation, repeated 8 hourly Duration Treatment for 7 days should be satisfactory for most patients but depending on clinical and bacteriological assessments, the physician may decide to prolong the treatment Infusion rate Filmet should be infused at an approximate rate of 5 ml/minute
CONTRAINDICATIONS
Known hypersensitivity to metronidazole.
PRECAUTIONS
Regular clinical and laboratory monitoring are advised if administration of Filmet for more than
10 days is considered to be necessary. Metronidazole should be administered with caution to
patients with hepatic encephalopathy. Caution is advised in patients with active disease of the
central nervous system other than brain abscess. The consumption of alcohol during
metronidazole therapy should be avoided since there could be a disulfiram-like reaction.
USE IN PREGNANCY& LACTATION
There is inadequate evidence of the safety of metronidazole in pregnancy. Metronidazole is
excreted in milk and no adverse effects in the newborn have been reported. Filmet should
therefore be given during pregnancy or during lactation only when the physicians consider it
essential.
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