Indications
Short-term treatment of insomnia.
Sedation in premedication before surgical or diagnostic procedures.
Dosage & Administration
Oral dosage: For adults 7.5-15 mg daily. In elderly and debilitated patients, the recommended dose is 7.5 mg. In premedication, 15 mg of Midazolam should be given 30-60 minutes before the procedure.
Intravenous administration:
Endoscopic or Cardiovascular Procedures
In healthy adults the initial dose is approximately 2.5 mg. In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg.
Induction of Anesthesia
The dose is 10-15 mg I. V.
Intramuscular administration:
Adult: 0.07-0.1 mg/kg bodyweight i. m. Usual dose is about 5 mg.
Children: 0.15-0.20 mg/kg.
Elderly and debilitated patients: 0.025-0.05 mg/kg
Rectal administration in children:
For preoperative sedation, rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min before induction of general anesthesia.
Side Effects
At the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Midazolam, fluctuations in vital signs have been noted including respiratory depression, apnoea, variations in blood pressure and pulse rate.
Precautions
Midazolam IV should be administered very slowly.
Contraindications
Midazolam must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome and with known hypersensitivity to benzodiazepines or to any component of the product.
Use in Pregnancy & Lactation
Midazolam should be avoided during pregnancy unless there is no safer alternative. Since Midazolam passes into breast milk, it should not be administered to breast-feeding mothers.
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