Indications
Therapeutic Class
Pharmacology
Dosage & Administration
Curative treatment of malaria with a single dose-
- Adults: 2-3 tablets
- Children under 4 years: ½ tablets
- 4-8 years: 1 tablet
- 9-14 years: 2 tablets
In severe cases, Sulphadoxine & Pyrimethamine can be beneficially combined with quinine.
Suppressive or prophylactic management-
The dose given below should be taken at one time:
For semi-immune subjects (Dose: once every four weeks)-
- Adults: 2-3 tablets
- Children under 4 years: ½ tablets
- 4-8 years: 1 tablet
- 9-14 years: 2 tablets
For non-immune subjects (Dose: Once every two weeks)-
- Adults: 2 tablets
- Children under 4 years: 1½ tablets
- 4-8 years: 1 tablet
- 9-14 years: 1½ tablets
For malaria prophylaxis:Â The first dose of Sulphadoxine & Pyrimethamine should be taken one or two days before departure for an endemic area in order to protect tolerance, administration should be continued in the above dosage during the stay and also for four weeks after return or as prescribed by the physician.
Interaction
Contraindications
Side Effects
Sulphadoxine & Pyrimethamine at the recommended dose is well tolerated. Main side effects are given below
- Skin reactions: Drug rash, pruritus and slight hair loss have been observed.
- Gastro-intestinal reactions:Â Feeling of fullness, nausea, rarely vomiting, stomatitis.
- Haematological reactions: In rare cases, leukopenia, thrombocytopenia, and megaloblastic anemia have been observed.
- Other reactions: Fatigue, headache, fever, polyneuritis may occasionally occur.
Pregnancy & Lactation
Sulphadoxine & Pyrimethamine is contraindicated during pregnancy, premature and newborn infants during the first weeks of life and intolerance to sulfonamide. If pregnancy can not be excluded, possible risks should be balanced against therapeutic effect.
Both Pyrimethamine and Sulphadoxine are excreted in maternal breast milk. Nursing mother should not take this preparation.
Reviews
There are no reviews yet.