Mezest 160mg 1pcs

Megestrol Acetate is used in anorexia, cachexia or a significant weight loss. Megestrol Acetate is also indicated for the palliative treatment of advanced carcinoma of the breast (i.e. recurrent, inoperable or metastatic diseases). It should not be used in lieu of currently accepted procedures such as surgery, radiation or chemotherapy.

Megestrol Acetate is a synthetic progestational anticancer drug. It may work by interfering with the hormone balance in the body, which may stop the cancer growing. It may also act directly on cancer cells so that they can’t grow. Moreover, Megestrol Acetate causes weight gain by increasing the fat and body cell mass and this weight gain is associated with increased appetite. Therefore this drug is used as an appetizer for the cancer patients suffering from anorexia, significant weight loss or cachexia.

Anorexia and cachexia in patients with cancer or AIDS:

• Initial: 800 mg daily.
• Usual range: 400-800 mg daily.

Palliative treatment of breast carcinoma: 40 mg 4 times daily or 160 mg once daily.

Palliative treatment of endometrial carcinoma: 40-320 mg daily in divided doses.

Concentrations of indinavir may be reduced. Possible reduced efficacy of cisplatin. Warfarin half life may be increased. Megestrol concentration may be decreased by aminoglutethimide and enzyme-inducing drugs.

Allergy to Megestrol acetate or any of the excipients. Women of child bearing potential should be advised to avoid becoming pregnant.

Side Effects: Nausea, vomiting, edema occur in approximately 1% to 2% of patients. Dyspnea, pain, hypertension, hot flashes, sweating mood changes, hyperglycemia, alopecia, asthenia, malaise, lethargy, rash, flatulence, diarrhoea and impotence have been reported. Constipation and urinary frequency have been reported in patients who received high doses of Megestrol acetate in clinical trials.Adverse effects:

• Thromboembolic phenomena: Thromboembolic phenomena including thrombophlebitis and pulmonary embolism (in some cases fatal) have been reported.
• Other adverse reactions: Breakthrough uterine bleeding occur in approximately 1% to 2% of patients. Heart failure, cushingoid facies, tumor flare (with or without hypercalcemia), carpal tunnel syndrome and urticaria have been reported.

Pregnancy category D. Megestrol Acetate can cause fetal abnormalities and risks, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.Nursing mothers: Very small amounts (approximately 0.1%) are excreted in mother’s milk. It is however, not known whether these amounts exert any harmful effect on the newborn. Because of the potential for adverse effects on the new born, nursing should be discontinued during treatment with Megestrol Acetate.