Brand Name: Migranil 1.5
Manufacturer: Square Pharmaceuticals Ltd.
INDICATION
Migranil® (Pizotifen) is chiefly indicated for the prophylactic treatment of
vascular headaches of the migraine type such as classical migraine,
common migraine and cluster headache.
DOSAGE AND ADMINISTRATION
Adults: The initial adult dose is 1.5 mg daily, this may be taken at bed time
as a single dose or in three divided doses.
Dosage can be adjusted according to individual patients’ requirements up
to a maximum of 4.5 mg daily. Up to 3 mg may be given as a single daily
dose.
Children: Up to 1.5 mg daily, usually as a divided dose. Use of 1.5 mg at a
time is not recommended, but up to 1 mg has been given as a single daily
dose at night.
Pizotifen
Anti-Migraine
Migranil®
CONTRAINDICATION AND PRECAUTION
It is contraindicated in patients hypersensitive to the drug.
Pizotifen should probably not be administered in presence of narrow-angle
glaucoma or prostate hypertrophy. Dosage adjustment may be necessary in
patients with kidney insufficiency.
Patients should be warned about the possibility of drowsiness and it’s
significance in the driving of vehicles and the operation of machinery. The
central effects of sedatives, hypnotics, antihistamines and alcohol may be
enhanced.
Caution is required in patient with urinary retention, closed angle glaucoma
and renal impairment.
SIDE EFFECT
The most commonly occurring side effects are drowsiness and an increase
in appetite which may lead to increase in body weight.
Other side effects such as dizziness, dry mouth, nausea and constipation
have been reported infrequently. In children, CNS stimulation may occur.
DRUG INTERACTION
Patients should be warned that their tolerance to alcohol may be lowered.
Pizotifen may increase and prolong the drowsiness that occurs as an
adverse effect of concurrently used tranquilizers, hypnotics and
antidepressants. It should not be used in patients receiving monoamine
oxidase inhibitors.
USE IN PREGNANCY AND LACTATION
As clinical data with Pizotifen in pregnancy is very limited, it should only be
administered during pregnancy under compelling circumstances.
It’s use in nursing mother is not recommended.
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