Indications
Management of hypertension where therapy with either a calcium channel blocker or a beta-blocking drug proves inadequate.Management of chronic stable angina pectoris where therapy with calcium channel blocker or a β-adrenoceptor blocking drug proves inadequate.
Therapeutic Class
Pharmacology
Atenolol belongs to a group of medicines called beta-blockers. It has an effect on the heart by blocking the action of chemicals called noradrenaline and adrenaline on beta receptor and control its rate and rhythm of beating. By reducing the heart rate and the force of muscle contraction, atenolol reduces the need of heart muscle for oxygen (demand). Because angina occurs when oxygen demand of the heart exceeds supply, atenolol is helpful in treating angina.Nifedipine belongs to a group of medicines called calcium-channel blockers. These medicines block the transport of calcium, via holes called channels, into the smooth muscle cells lining the heart blood vessels and other blood vessels of the body. Blocking calcium transport relaxes the muscles of the blood vessels and makes them wider.
Dosage & Administration
Adult:
- Hypertension : One capsule daily swallowed with water. If necessary, the dosage may be increased to 1 capsule dosed every 12 hours.
- Angina : One capsule every 12 hours swallowed with water. Where additional efficacy is necessary, prophylactic nitrate therapy or additional nifedipine may be of benefit.
Elderly: Dosage should not exceed 1 capsule daily in hypertension or 1 capsule twice daily in angina.
Pediatric: Safety and effectiveness in pediatric patients have not been established.
Interaction
Contraindications
Side Effects
The following undesired events have been reported:
- Cardiovascular: flushing, edema
- CNS: dizziness, headache
- Gastrointestinal: gastrointestinal disturbance
- Haematological: purpura
- Reproductive: impotence
- Others: fatigue
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