Pantodac 40mg 1pcs

Indications
Pantoprazole is indicated where suppression of acid secretion is of therapeutic benefit. Pantoprazole Is registered in the foltawing indications:
Peptic ulcer diseases (PUD)
Gastro-esophageal reflux diseases
Treatment of ulcer resistant to M2 blocker
Treatment of ulcer induced by NSAIDs
Gl bleeding from stress or acid peptic diseases
Eradication of Helicobacter pylori
Zollinger-Ellison syndrome
Prophylaxis for acid aspiration syndrome during induction of anesthesia
Therapeutic Class
Proton Pump Inhibitor
Pharmacology
Pantoprazole is chemically a novel substituted benzimidazole derivative, which suppresses the final step in gastric acid production by forming a covalent bond to two sites of H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. This leads to inhibition of both basal and stimulated gastric effect that persists longer than 24 hours.

Pantoprazole is quantitatively absorbed and its bioavailability does not change upon multiple dosing. Pantoprazole is extensively metabolized in the liver. Almost 80% of an oral dose is excreted as metabolites in urine; the remainder is found in feces.
Dosage
Tablet:
The usual recommended adult oral dose is 40 mg given once daily, preferably in the morning with or without food. The duration of therapy is ranging from 2-8 weeks.
Duodenal ulcers: Pantoprazole 40 mg tablet once daily for 2-4 weeks.
Gastric ulcer: Pantoprazole 40 mg tablet once daily for 4-8 weeks.
Reflux esophagitis: Pantoprazole 40 mg tablet once daily for 4-8 weeks.
Ulcers induced by NSAIDs: Pantoprazole 40 mg tablet once daily.
Maintenance therapy: Maintenance therapy should involve the lowest effective dose of the drug. Pantoprazole both 20 mg & 40 mg doses are safe and effective in maintaining patients with healed reflux esophagitis and PUD in remission.
Administration
DIRECTION FOR USE OF IV INJECTION: Pantoprazole lyophilized powder and 0.9% Sodium Chloride Injection is for intravenous administration only and must not be given by any other route. Pantoprazole IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by adding 10 ml 0.9% Sodium Chloride Injection to the vial containing powder. After reconstitution the injection should be given slowly over a period of at least 2 to 5 minutes. Use only freshly prepared solution. The reconstituted solution may be stored at room temperature (up to 30° C) for a maximum 4 hours.

DIRECTION FOR USE OF IV INFUSION: Pantoprazole IV infusion should be given as an intravenous infusion over a period of approximately 15 minutes. Pantoprazole IV infusion should be reconstituted with 10 ml of 0.9% Sodium Chloride Injection and further diluted (admixed) with 0.9% Sodium Chloride Injection or 5% Dextrose or Lactated Ringer’s Injection to a final volume of 100 ml. The reconstituted solution may be stored at room temperature (up to 30° C) for a maximum 4 hours prior to further dilution. The admixed solution may be stored at room temperature (up to 30° C) and must be used within 24 hours from the time of initial reconstitution.
Interaction
There is no interaction with concomitantly administered antacids. No dosage adjustment is needed with combination use of the following drugs: Theophylline, Caffeine, Diazepam, Digoxin, Ethanol, Metoprolol, Nifedipine or Warfarin.
Contraindications
It is contraindicated in patients with known hypersensitivity to Pantoprazole.
Side Effects
No potentially life-threatening effects have been reported with Pantoprazole. Symptomatic adverse effects include headache and diarrhoea are two common reported adverse effects. Peripheral edema has been occasionally reported in female patients. Other side effects may include abdominal pain, dizziness, nausea, epigastric discomfort, flatulence, skin rash, pruritus etc.