Indications : Duodenal ulcer, gastric ulcer, heart burn, NSAID-associated complications, peptic ulcer associated with Helicobacter pylori, gastro-esophageal reflux disease, acid reflux disease, Zollinger-Ellison syndrome, prevention of acid aspiration syndrome, acid related dyspepsia and other hyper acidic complications.
Dosage & Administration : Benign gastric and duodenal ulcers : 20 mg once daily for 4 weeks in duodenal ulceration or 8 weeks in gastric ulceration; in severe or recurrent cases increase to 40 mg daily; Maintenance for recurrent duodenal ulcer : 20 mg once daily; Prevention of relapse in duodenal ulcer : 10 to 20 mg once daily if symptoms return. Heart burn : 20 mg once daily for 14 days. NSAID-associated complications : 20 mg once daily for 4 weeks. Gastro-esophageal reflux disease : 20 mg once daily for 4 weeks, followed by a further 4-8 weeks if not fully healed. Acid reflux disease (long-term management) : 10 to 20 mg once daily if symptoms return. Zollinger-Ellison syndrome : Initially 60 mg (40 + 20 mg) once daily; usual range 20 – 120 mg daily (above 80 mg in 2 divided doses). Gastric acid reduction during general anaesthesia (prophylaxis of acid aspiration) : 40 mg on the preceding evening, then 40 mg 2 – 6 hours before surgery. Acid related dyspepsia : 10 – 20 mg once daily for 2 – 4 weeks according to response. Helicobacter pylori Associated Ulcer : Omeprazole (PPI) 20 mg twice daily. Amoxicillin (Moxilin) 1 g twice daily. Clarithromycin (Claricin) 500 mg twice daily, 01 – 02 weeks. Omeprazole (PPI) 20 mg twice daily. Clarithromycin (Claricin) 500 mg twice daily. Metronidazole (Dirozyl) 500 mg twice daily, 01 – 02 weeks.Omeprazole (PPI) 20 mg twice daily. Amoxicillin (Moxilin) 1 g twice daily. Metronidazole (Dirozyl) 500 mg twice daily, 01 – 02 weeks.
Impaired renal or hepatic function : Dose adjustment is not required in renal impairment.
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