INDICATIONS
Benign gastric and duodenal ulcer, Reflux esophagitis, NSAID-associated ulceration, Chronic episodic dyspepsia, Zollinger-Ellison syndrome, Gastric acid reduction (prophylaxis of acid aspiration) in obstetrics and in surgical procedures.
DOSAGE AND ADMINISTRATION
Tablet & Syrup : Benign gastric and duodenal ulcer : 150 mg (2 teaspoonful) twice daily or 300 mg (4 teaspoonful) at night for 4-8 weeks.
Maintenance dose : 150 mg (2 teaspoonful) at night. Reflux esophagitis : 150 mg (2 teaspoonful) twice daily or 300 mg (4 teaspoonful) at night for up to 8 weeks, or if necessary 12 weeks [moderate
to severe, 150 mg (2 teaspoonful) 4 times daily for up to 12 weeks].
Long-term treatment of healed esophagitis : 150 mg (2 teaspoonful) twice daily. Zollinger-Ellison syndrome : 150 mg (2 teaspoonful) 3 times daily; doses up to 6 g daily in divided doses have been used. NSAIDassociated ulceration : 150 mg (2 teaspoonful) twice daily or 300 mg (4 teaspoonful) at night for up to 8 weeks. Prophylaxis of NSAID-induced duodenal ulcer : 150 mg (2 teaspoonful) twice daily. Chronic episodic dyspepsia : 150 mg (2 teaspoonful) twice daily or 300 mg (4 teaspoonful) at night for up to 6 weeks. Gastric acid reduction (prophylaxis of acid aspiration) in obstetrics : 150 mg (2 teaspoonful) at onset of labour, then every 6 hours; Surgical procedures : 150 mg (2 teaspoonful) two hours before induction of anaesthesia, and also, when possible on the preceding evening.
Children (Peptic ulcer) : 2-4 mg/kg twice daily to a maximum of 300 mg (4 teaspoonful) daily.
Injection : RANIDIN injection is administered intramuscularly or
intravenously. By intramuscular injection, 50 mg every 6-8 hours. By slow intravenous injection, 50 mg diluted to 20 ml and given over at least 2 minutes; may be repeated every 6-8 hours. By intravenous infusion, 25 mg/hour for 2 hours; may be repeated every 6-8 hours. Prophylaxis of
stress ulceration, initial slow intravenous injection of 50 mg then continuous infusion, 0.125-0.250 mg/kg/hour. Surgical procedures, by intramuscular or intravenous injection, 50 mg 45-60 minutes before induction of anaesthesia (intravenous injection diluted to 20 ml and given over at least 2 minutes).
OR AS DIRECTED BY THE PHYSICIAN
SIDE EFFECTS
Ranitidine is usually well tolerated. Headache, dizziness, rash, tiredness and gastrointestinal disturbances may occur.
CONTRAINDICATIONS
Ranitidine is contraindicated in patients with known hypersensitivity to the drug.
PRECAUTIONS
Ranitidine should be used with caution in hepatic impairment, renal impairment, pregnancy (Pregnancy category B) and breast-feeding.
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