Description
Cefuroxime is one of the bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. It is indicated for the treatment of infections caused by sensitive bacteria.
Rofurox® 250 tablet : Each film coated tablet contains Cefuroxime Axetil USP equivalent to cefuroxime 250 mg.
Rofurox® 500 tablet : Each film coated tablet contains Cefuroxime Axetil USP equivalent to cefuroxime 500 mg.
Rofurox® dry powder for suspension: After reconstitution according to direction, each 5 ml suspension contains Cefuroxime Axetil USP equivalent to Cefuroxime 125 mg.
Rofurox® 750 mg IM/IV injection: Each vial contains Cefuroxime Sodium USP equivalent to Cefuroxime 750 mg.
Dosage and Administration
Usual dose: The usual adult dosage range is 750 mg to 1.5 grams every 8 hours, usually for 5 to 10 days. In uncomplicated urinary tract infections, skin and skin-structure infections, disseminated gonococcal infections, and uncomplicated pneumonia, a 750-mg dose every 8 hours is recommended. In severe or complicated infections, a 1.5-gram dose every 8 hours is recommended. In bone and joint infections, a 1.5-gram dose every 8 hours is recommended. Surgical prophylaxis: A 1.5-gram dose administered intravenously just before surgery (approximately one-half to 1 hour before the initial incision) is recommended. Thereafter, give 750 mg intravenously or intramuscularly every 8 hours when the procedure is prolonged. Pediatric Patients Above 3 Months of Age: Administration of 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours has been successful for most infections susceptible to cefuroxime.
Generally Cefuroxime is well tolerated. However has been associated with nausea and vomiting in a small number of patients.
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