Product Details
Rupatadine is a long-acting, non-sedative antagonist of histamine H1-receptors. It also antagonizes the platelet-activating factor (PAF). Both histamine and PAF cause bronchoconstriction which leads to an increase in the vascular permeability and act as a mediator in the inflammatory process. Rupatadine possesses other anti-allergic properties such as the inhibition of the degranulation of mast cells induced by immunological and non-immunological stimuli and inhibition of the release of cytokines, particularly of the tumor necrosis factor alpha (TNFa) in human mastocytes and monocytes.Ltd.
Rupa Tablet:Â Each tablet contains Rupatadine Fumarate INN equivalent to Rupatadine 10 mg.
Rupa Oral Solution: Each 5 ml oral solution contains Rupatadine Fumarate INN equivalent to Rupatadine 5 mg.
Indication
Rupatadine is indicated for the symptomatic treatment of seasonal & perennial allergic rhinitis and urticaria.
Dosage and Administration:
Rupa Tablet: The recommended dosage is 10 mg once daily, with or without food.
Rupa Oral Solution: Children aged 2 to 11 year: Children weighing 25 kg or more : 1 teaspoonful (5 ml) of oral solution once daily with or without food. Children weighing equal or more than 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) oral solution once daily with or without food.
Side Effect
The most common undesirable effects are sleepiness, general weakness & fatigue.
Drug Interection:
CYP3A4 inhibitors like Erythromycin & Ketoconazole inhibits both the presystemic and systemic metabolism of Rupatadine. Due to this potential interaction, it is not recommended to use Rupatadine in combination with Ketoconazole or any other inhibitors of CYP3A4. Coadministration of Rupatadine and CNS depressants or alcohol may increase CNS depressant effect.
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