Brand Name:Â Xenole
Manufacturer:Â Square Pharmaceuticals Ltd.
Indications
Allergic Rhinitis: Desloratadine is indicated for the relief of the nasal and non-nasal symptoms of allergic rhinitis (Both seasonal and perennial) in patients 2 years of age and older.
Chronic Idiopathic Urticaria: Desloratadine is also indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 2 years of age and older.
Therapeutic Class
Non-sedating antihistamines
Pharmacology
Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Dosage & Administration
Pediatric drops :
Child 6 -11 months of age: 2 ml drops once daily
Child 1 -2 years of age: 2.5 ml drops once daily
Syrup:
Child 6-11 months of age: 2 ml once daily
Child 1-5 years of age: 2.5 ml once daily
Child 6-11 years of age: 5 ml once daily
Adults & > 12 years of age: 10 ml once daily
Tablet:
Adults and children 12 years of age and over: 5 mg daily
Interaction
Concomitant administration of Erythromycin, Ketoconazole, Azithromycin, Fluoxetine, and Cimetidine with Desloratadine increased the plasma concentration of Desloratadine. But there were no clinically relevant changes in the safety profile of Desloratadine.
Contraindications
Desloratadine is contraindicated in patient having hypersensitivity to this medication or to any of its ingredients or Loratadine.
Side Effects
Desloratadine is generally well tolerated. However, dry mouth, fatigue, somnolence and myalgia are commonly reported side-effects. Less common side-effects may include dizziness, headache and nausea. Rarely rash, pruritus and urticaria may occur.
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