Indications
Therapeutic Class
Pharmacology
Dosage & Administration
Prophylaxis of surgical infection in patients undergoing prostate surgery:
- Adult:Â 1 g at induction of anaesth repeated if necessary upon removal of catheter. It is given as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
- Elderly: >80 yr Max: 3 g daily.
Pseudomonal lung infections in cystic fibrosis:
- Adult:Â 100-150 mg/kg 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min. Max: 9 g daily.
- Child:Â <40 kg: 150 mg/kg daily in 3 divided doses. Max: 6 g daily.
- Elderly: >80 yr Max: 3 g daily
Bone and joint infections, Complicated intra-abdominal infections, Skin and skin structure infections, complicated:
- Adult:Â 1-2 g 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
- Child:Â <40 kg: 100-150 mg/kg daily in 3 divided doses. Max: 6 g daily.
- Elderly: >80 yr Max: 3 g daily.
Bacterial meningitis, Empiric therapy for febrile neutropenic patients, Nosocomial pneumonia:
- Adult:Â 2 g 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
- Child:Â <40 kg: 150 mg/kg daily in 3 divided doses. Max: 6 g daily.
- Elderly: >80 yr Max: 3 g daily.
Complicated urinary tract infections:
- Adult:Â 1-2 g 8-12 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
- Child:Â <40 kg: 100-150 mg/kg daily in 3 divided doses. Max: 6 g daily.
- Elderly: >80 yr Max: 3 g daily.
Interaction
Contraindications
Side Effects
Pregnancy & Lactation
Pregnancy: No adequate and well controlled studies in pregnant women have been conducted with Ceftazidime. Because animal reproduction studies are not always predictive of human response this drug should be used during pregnancy only if clearly needed.
Lactation: Ceftazidime is excreted in human milk in low concentrations. Because many drugs are excreted in human milk and because safety of the component of the injections in nursing infants has not been established, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Precautions
Overdose Effects
Symptoms: Seizure activity, encephalopathy, asterixis, neuromuscular excitability, coma.
Management: Symptomatic and supportive treatment. In the presence of renal insufficiency, haemodialysis or peritoneal dialysis may aid in the removal of the drug from the body.
Reconstitutions
Single-dose vial Administration Amount of WFI to be added:
- 250 mg IM in 1.5 ml
- 250 mg IV in 5 ml
- 500 mg IM in 1.5 ml
- 500 mg IV in 5 ml
- 1 gm IM in 3 ml
- 1 gm IV in 10 ml
Step 1:Â Add recommended volume of solvent slowly. Remove the syringe needle.
Step 2:Â Gently shake the vial to dissolve the powder. Carbon dioxide is released & a clear solution will be obtained.
Step 3:Â Now insert the needle in the free space of the reconstituted vial & withdraw the pressurized air from the free space.
Step 4:Â Finally withdraw the solution from the vial by syringe
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