Spotclen Plus 10gm

Each gram cream contains-

• Hydroquinone 40 mg
• Octyldimethyl P-aminobenzoate 80 mg
• Dioxybenzone 30 mg
• Oxybenzone 20 mg

Hydroquinone is indicated –

• For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.
• To reduce hyperpigmentation caused by photosensitization associated with inflammation or with the use of certain cosmetics.

Sunblock Preparation

Hydroquinone is a topical depigmentating agent used in hyperpigmentation conditions by suppressing melanocyte metabolic processes. It also increases melanin excretion from melanocytes and prevents its production.

Octyldimethyl P-aminobenzoate is used topically as a sunscreen. It is used to prevent sunburn, but unlikely to prevent drug-related or other photosensitivity reactions associated with UVA light.

Dioxybenzone (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. It is a derivative of benzophenone. It is a yellow powder with a melting point of 68 °C. It is insoluble in water, but moderately soluble in ethanol and isopropanol.

Oxybenzone: Although benzophenones are primarily UV-B absorbers, oxybenzone absorbs well through UV-A II. Oxybenzone can be considered a broad-spectrum absorber. It significantly augments UV-B protection when used in a given formula.

Adult: This cream should be applied to the affected area and rubbed in well twice daily or as directed by a physician. Most discolorations begin to lighten after 3 or 4 weeks of treatment but it may take longer. After desired bleaching, use only as needed to maintain results of treatment. After reduction of hyperpigmentation, use of sunscreen agents and/or protective clothing should continue on bleached skin to prevent repigmentation.

Children: Safety and efficacy in paediatric patients below the age of 12 years have not been established.

There are no known drug interactions and none well documented.

Hydroquinone is contraindicated to patients with prior history of hypersensitivity or allergic reaction to hydroquinone or other ingredients in the preparation. Sunburn or depilatory usage. Children <12 yr.

Transient erythema, mild burning sensations; hyperpigmentation. Staining and corneal opacities. Tremors and convulsions after systemic absorption. Occasionally, hypersensitivity.

Pregnancy Category-C. It is not known whether this cream can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used in pregnant woman only when clearly indicated.

Lactation: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother.