Brand Name:Â Tofen
Manufacturer:Â Beximco Pharmaceuticals Ltd.
Description
Tofen is a preparation of Ketotifen, which has antiallergic properties and has been used similarly, to Sodium Chromoglycate in the prophylactic treatment of asthma. It also has the properties of an antihistamine.
Tofen possesses marked anti-anaphylactic properties and is effective in preventing asthmatic attack. Tofen exerts sustained inhibitory effect on histamine reactions, which can be clearly dissociated from its antianaphylactic properties. Experimental investigations in asthmatic subjects have shown that Ketotifen is as effective orally as administered by inhalation as a selective mast cell stabiliser. Antihistamines were
ineffective in those tests. The effectiveness of Ketotifen has been studied in long term clinical trials. Asthma attacks were reduced in number severity and duration and in some cases, the patients were completely
freed from attacks. Progressive reduction of corticosteroids and/or bronchodilators was also possible. The prophylactic activity of Tofen may take several weeks to become fully established. Tofen will not abort
established attacks of asthma.
- Indications
- ¨ Prophylactic treatment of bronchial asthma.
- ¨ Symptomatic treatment of allergic conditions including rhinitis and
- conjunctivitis.
- Dosage and Administration
- Adults : 1 mg twice daily with food. If necessary the dose may be
- increased to 2 mg twice daily in severe cases. Children above 2 (two) years
- 1 mg twice daily with food. Patient’s known to be easily sedated should
begin treatment with 0.5 to 1 mg at night for the first few days or as
directed by the physician. Use in elderly : Same as adult dose or as advised
by the physician.
Side Effects
Drowsiness and in isolated cases, dry mouth and slight dizziness may
occur at the beginning of treatment, but usually disappear spontaneously
after a few days.
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