Indications
Trihexyphenidyl HCl tablets are indicated as an adjunct treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic & idiopathic). Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as dibenzoxazepines, phenothiazines, thioxanthenes & butyrophenones.
Dosage & Administration
Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether Trihexy (trihexyphenidyl HCl) may best be given before or after meals should be determined by the way the patient reacts.
Idiopathic Parkinsonism
1 mg of Trihexy (trihexyphenidyl HCl) tablet maybe administered the first day. The dose may then be increased by 2mg increments at intervals of three to five days.
Drug-Induced Parkinsonism
Commence therapy with a single 1 mg dose increase the total daily dosage to 5-15 mg range if the extrapyramidal manifestations are not controlled.
Concomitant Use with Levodopa
When Trihexy (trihexyphenidyl HCl) is used concomitantly with levodopa, the usual dose is 3-6 mg daily.
Side Effects
Minor side effects such as dryness of the mouth, blurring of vision, dizziness, mild nausea or nervousness. Patients with arteriosclerosis or with a history of idiosyncrasy to other drugs may exhibit reactions of mental confusion, agitation, disturbed behavior, or nausea and vomiting. Potential side effects are constipation, drowsiness, urinary hesitancy or retention, pupil dilation, increased intraocular tension, vomiting and headache
Contraindications
Trihexyphenidyl is contraindicated in patients with hypersensitivity in patients to trihexyphenidyl HCl or to any of the tablet or elixir ingredients. Trihexyphenidyl is also contraindicated in patients with narrow angle glaucoma. Blindness after long-term use due to narrow angle glaucoma has been reported.
Use in Pregnancy & Lactation
Pregnancy: Pregnancy Category C.
Nursing mothers: It is not known whether the drug is excreted in human milk and therefore trihexyphenidyl should only be used if the expected benefit to the mother outweighs the potential risk to the infant.
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