- Repigmentation of vitiliginous areas: As 1% soln (diluted to 0.1-0.01%): Apply over lesions then expose to UVA immediately after application or wait up to 2 hr. Protect the area surrounding the lesion with a sunscreen. Wash and protect lesions from light after treatment; protection may be up to ≥48 hr. Treatment is usually repeated once wkly. Substantial repigmentation usually requires 6-9 mth of treatment.
- Psoriasis: As a 0.15% soln (diluted to 0.015%, if necessary): Apply to affected areas 15 min before UVA exposure. Alternatively, patient may take a whole body bath in methoxsalen soln for 15 min followed by immediate UVA exposure. For treating affected areas, immerse the affected areas for 15 min into 3 mg/L soln of hand and foot soaks followed by a 30-min delay before UVA exposure. Baths or soaks are given twice wkly.
Geriatric use: Refer to adult dosing.
Pediatric use (Children ≥12 years): Vitiligo: Refer to adult dosing.
Repigmentation of vitiliginous areas: 20 mg or up to 600 mcg/kg 2-4 hr before measured periods of UVA exposure depending on the preparation, given twice wkly or on alternate days, with at least 48-hr intervals.
Psoriasis: Up to approx 600 mcg/kg, given 1.5-3 hr before UVA exposure, depending on the preparation. Treatment is usually given twice wkly or increased as necessary, with at least 48-hr intervals between doses. If there is no or minimal response after the 15th PUVA treatment, dose may be increased by 10 mg and this dose used for the remainder of the treatment course.
Major Side Effects are-
- Blistering and peeling of skin
- reddened, sore skin
- swelling, especially of the feet or lower legs
There is an increased risk of developing skin cancer after use of methoxsalen. You should check the treated areas of your body regularly and show your doctor any skin sores that do not heal, new skin growths, and skin growths that have changed in the way they look or feel.
Premature aging of the skin may occur as a result of prolonged methoxsalen therapy. This effect is permanent and is similar to the result of sunbathing for long periods of time.