Brand Name: Bislol Plus 5
Manufacturer: Opsonin Pharma Ltd.
Indications
Bisoprolol plus Hydrochlorothiazide is indicated in the treatment of Hypertension.
Therapeutic Class
Combined antihypertensive preparations
Pharmacology
Bisoprolol is a beta1 selective (cardio selective) adrenoceptor blocking agent without significant membrane stabilizing activity or intrinsic sympathomimetic activity in its therapeutic dosage range.
Dosage & Administration
Bisoprolol is an effective treatment of hypertension in once daily doses of 2.5 to 40 mg, while Hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials of Bisoprolol/Hydrochlorothiazide combination therapy using Bisoprolol doses of 2.5 to 20 mg and Hydrochlorothiazide doses of 6.25 to 25 mg, the antihypertensive effects increased with increasing doses of either component.
Interaction
This combination drug may potentiate the action of other antihypertensive agents when used concomitantly. This combination drug should not be combined with other beta-blocking agents. Patients receiving catecholamine depleting drugs, such as reserpine or guanethidine, should be closely monitored because the added beta adrenergic blocking action of Bisoprolol may produce excessive reduction of sympathetic activity. This combination should be used with caution when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists verapamil and benzothiazepine diltiazem classes or anti-arrhythmic agents, such as disopyramide, are used concurrently. Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate.
Contraindications
It is contraindicated in patients in cardiogenic shock, overt cardiac failure, second or third degree AV block, marked sinus bradycardia, anuria and hypersensitivity to either component of this product or to other sulfonamide derived drugs.
Side Effects
Generally well tolerated. Most side effects have been mild and transient. Side effects which may occur: fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, rhythm disturbances, cold extremities, claudication, orthostatic hypotension, diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis etc.
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