INDICATIONS & USES
Symptomatic treatment of chronic stable angina pectoris in coronary artery disease
patients with normal sinus rhythm.Ivanor
TM
is indicated:
In patients unable to tolerate or with a contra-indication to the use of beta-blockers,
or
In combination with beta-blockers in patients inadequately controlled with an
optimal beta-blocker dose and whose heart rate is > 60 bpm.
DOSAGE AND ADMINISTRATION
The usual recommended starting dose of Ivabradine is 5 mg twice daily which may be
increased after 3-4 weeks of treatment to 7.5 mg twice daily, depending on therapeutic
response. Usual dose is 1 tablet in the morning and 1 tablet in the evening during
meals.
If the heart rate decreases persistently below 50 bpm at rest or if symptoms related to
bradycardia, the dose must be adjusted downwards to 2.5mg twice daily (one half of
the 5 mg tablet twice daily). Treatment must be discontinued if heart rate remains
below 50 bpm or symptoms of bradycardia persist.
Elderly: Consider a lower starting dose (2.5 mg twice daily i.e. one half 5 mg tablet twice
daily).
Renal insufficiency: Use with caution in patients with creatinine clearance <15 ml/min.
Hepatic impairment: Use with caution in patients with moderate hepatic impairment;
contra-indicated in severe hepatic impairment.
Children and adolescents: Not recommended.
CONTRAINDICATIONS
History of hypersensitivity to Ivabradine or any of the excipients, resting heart rate
below 60 bpm before treatment, cardiogenic shock, acute myocardial infarction,severe
hypotension (< 90/50 mmHg), severe hepatic insufficiency, sick sinus syndrome, sinoatrial
block, heart failure, pacemaker dependent, unstable angina, 3rd degree AV block,
combination with strong cytochrome P-450 3A4 inhibitors (such as azole antifungals,
macrolide antibiotics,HIV protease inhibitors).
PRECAUTION
Mild to moderate hypotension, atrial fibrillation, patients with congenital QT syndrome
or treated with QT wave prolonging medicinal products, Moderate hepatic
insufficiency,severe renal insufficiency.
DRUG INTERACTION
QT wave prolonging medicinal products is not recommended.
Cardiovascular QT wave prolonging medicinal products (e.g.quinidine,
disopyramide, bepridil,sotalol, ibutilide, amiodarone).Non cardiovascular QT wave
prolonging medicinal products (e.g.pimozide, ziprasidone,sertindole, mefloquine,
halofantrine, pentamidine, cisapride, intravenous erythromycin).
The concomitant use of cardiovascular and non cardiovascular QT wave prolonging
medicinal products with ivabradine should be avoided since QT wave prolongation
may be exacerbated by heart rate reduction. If the combination appears necessary,
close cardiac monitoring is needed.
SIDE EFFECT
Visual symptoms, blurred vision, bradycardia, 1st degree AV block, ventricular
extrasystoles, headaches, and dizziness.
USE IN FERTILITY,PREGNANCY AND LACTATION
Fertility: Studies in rats have shown no effect on fertility in males and females
Pregnancy: There are no or limited amount of data from the use of ivabradine in
pregnant women.Therefore, ivabradine is contra-indicated during pregnancy.
Breast-feeding: Animal studies indicate that ivabradine is excreted in milk. Therefore,
ivabradine is contra-indicated during breast-feeding.
STORAGE CONDITION
Store at cool and dry place, protect from light and moisture
Ivanor 5mg 10pcs
৳ 251
Description
Reviews (0)
Be the first to review “Ivanor 5mg 10pcs” Cancel reply
Reviews
There are no reviews yet.