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HomeMedicineTablet Winbac 500mg 1pcs
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Winbac 500mg 1pcs

৳ 16

Categories: Medicine, Tablet Brand: RADIANT PHARMACEUTICALS LTD.
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Description

Winbac

containing Ciprofloxacin is a synthetic quinolone anti-infective agent. Ciprofloxacion has broad spectrum of activity. It is active against most gram negative aerobic bacteria including Enterobacteriaceae and Pseudomonas aeruginosa. Ciprofloxacin is also active against gram-positive aerobic bacteria including penicillinase producing, non penicillinase producing, and methicillin resistant staphylococci, although many strains of streptococci are relatively resistant to the drug. The bactericidal action of Ciprofloxacin results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA.
Following oral administration it is rapidly and well absorbed from the G.I. tract. It is widely distributed into the body tissues and fluids. The half life is about 3.5 hours. About 30% to 50% of an oral dose of Ciprofloxacin is excreted in the urine within 24 hours as unchanged drug and biologically active metabolites.

Presentation:

Winbac® 500: Each film coated tablet contains Ciprofloxacin 500 mg as Ciprofloxacin Hydrochloride USP .

 Dosage and Administration

General dosage recommendations: The dosage of the Ciprofloxacin is determined by the severity and type of infection, the sensitivity of the causative organism(s) and the age, weight and renal function of the patient. Adults: The dosage range for adults is 100-750 mg twice daily. In infections of the lower and upper urinary tract (depending on severity): 250-500 mg twice daily. In respiratory tract infections: 250-500mg twice daily for both upper and lower respiratory tract infections, depending on the severity. For the treatment of known Streptococcus pneumonia infection, the recommended dosage is 750 mg twice daily. In gonorrhea: A single dose of 250 or 500 mg. In the majority other infections, 500-750 mg twice daily should be administered. Cystic fibrosis: In adults with pseudomonal infections of the lower respiratory tract , the normal dose is 750 mg twice daily. As the pharmacokinetics of Ciprofloxacin remain unchanged in patients with cystic fibrosis, the low body weight of these patients would be fallen into consideration when determining dosage. Impaired renal function: Dosage adjustment is not usually required except in patients with several renal impairment. (serum creatinine > 265 micro mol/l or creatinine clearance < 20ml/minute). If adjustment is necessary, this may be achieved by reducing the total daily dose by half, although monitoring of drug serum levels provide the most reliable basis for dose adjustment. Elderly: Although higher Ciprofloxacin serum levels are found in the elderly, no adjustment of dosage is necessary. Adolescents and children: As with other drugs in its class, Ciprofloxacin has been shown to cause arthropathy in weight bearing joints of immature animals. Although the relevance of this to man is unknown, its use in children, growing children and growing adolescents is not recommended. However, where the benefit of using Ciprofloxacin is considered to outweigh the potential risk, the dosage should be 7.5-15 mg/kg/day depending upon the severity of infection, administered in two divided doses. Duration of treatment: The duration of treatment depends upon the severity of infection, clinical response and bacteriological findings. For acute infections the usual treatment period is 5 to 10 days with Winbac® tablets. Generally treatment should be continued for three days after the signs and symptoms of the infection have disappeared.

 Side Effects

Gastrointestinal disturbances e.g. nausea, diarrhoea, vomiting, dyspepsia, abdominal pain.Disturbances of the central nervous system e.g. headache, dizziness, tiredness, confusion, convulsion. Hypersensitivity reactions e.g. skin rash (very rarely Stevens- Johnson syndrome and toxic epidermal necrolysis), pruritus and possible systemic reactions. The other less reported reactions are joint pain, mild photosensitivity and transient increase in liver enzymes (particularly in patients with previous liver damage), serum bilirubin, urea or creatinine levels.

Pregnancy & Lactation

Not to be used in pregnancy and nursing stage. Though not recommended for the children where benefit out- weighs risk, a dosage of 7.5 – 15 mg/kg/day in two divided doses can be given.
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Winbac 500mg 1pcs

৳ 16