Indications
Xenovate (Clobetasol Propionate) ointment and cream are indicated for the topical therapy of recalcitrant corticosteroid responsive dermatoses, including severe cases of psoriasis (excluding widespread plaque psoriasis) and eczematous dermatitis.
Xenovate (Clobetasol Propionate) ointment is generally chosen for dry, lichenified or scaly lesions or where a more occlusive effect is required.
Xenovate (Clobetasol Propionate) cream is suitable for moist or weeping lesions.
Dosage & administration
Xenovate (Clobetasol Propionate) ointment and cream are applied sparingly to cover the affected area, and gently rubbed into the skin. Frequency of application is two to three times daily according to the severity of the condition. The total dose of Clobetasol Propionate cream and ointment applied should not exceed 50grams weekly. Therapy should be discontinued if no response is noted after a week or as soon as the lesion heals. It is advisable to use Clobetasol Propionate (Xenovate) cream and ointment for brief periods only.
Drug interaction: There has been no report of interaction with Clobetasol Propionate ointment and cream.
Use in pregnancy & lactation: Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal development. The relevance of this finding to human beings has not been established. The safe use of Clobetasol Propionate during lactation has not been established. However, the administration of Clobetasol Propionate during pregnancy and lactation should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus. Drugs of this class should not be used extensively in pregnant patients in large amounts or for prolonged periods of time.
Side effects: As with other topical corticosteroids, prolonged use of large amounts of Clobetasol Propionate or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism. This effect is more likely to occur in infants and children, and if occlusive dressings are used. Local atrophy may occur after prolonged treatment. In rare instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked the pustular form of the diseases Clobetasol Propionate is usually well tolerated, but if signs of hypersensitivity appear, application should be stopped immediately
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